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  2. Hereditary haemochromatosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_haemochromatosis

    Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...

  3. Iron overload - Wikipedia

    en.wikipedia.org/wiki/Iron_overload

    However ferritin levels may be elevated due to a variety of other causes including obesity, infection, inflammation (as an acute phase protein), chronic alcohol intake, liver disease, kidney disease, and cancer. [7] [32] [33] In males and postmenopausal females, normal range of serum ferritin is between 12 and 300 ng/mL (670 pmol/L) .

  4. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    The mutation which causes sickle cell disease results in an abnormal hemoglobin known as hemoglobin S (HbS), which replaces HbA in adults. [20] The human genome contains a pair of genes for β-globin; in people with sickle cell disease, both genes are affected and the erythropoietic cells in the bone marrow will only create HbS.

  5. Woman to Woman: Causes, symptoms and treatments of sickle ...

    www.aol.com/woman-woman-causes-symptoms...

    NEW HAVEN, Conn. (WTNH) — Sickle cell disease is an inherited blood disorder impacting 100,000 people in the U.S., disproportionately people of color. Dr. Lila Van Doren, assistant professor of ...

  6. Beta thalassemia - Wikipedia

    en.wikipedia.org/wiki/Beta_thalassemia

    The treatment was approved in the United Kingdom for the treatment of transfusion-dependent beta-thalassemia in November 2023 [15] and in the United States in January 2024. [63] Exagamglogene autotemcel is the first cell-based gene therapy treatment utilizing CRISPR/Cas9 gene editing technology to be approved by the US Food and Drug ...

  7. Hemosiderosis - Wikipedia

    en.wikipedia.org/wiki/Hemosiderosis

    Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Selective iron deposition in the beta cells of pancreatic islets leads to diabetes [ 4 ] [ 2 ] due to the distribution of transferrin receptor on the beta cells of islets [ 3 ] and in the skin leads to hyperpigmentation.

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