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Valproic acid is fully ionized into valproate at the physiologic pH of the human body, and valproate is the active form of the drug. Sodium valproate is the sodium salt of valproic acid. Divalproex sodium is a coordination complex composed of equal parts of valproic acid and sodium valproate. [110]
Sodium valproate [note 1] Convulex, Depakene, Depakine Enteric, Orfiril, Stavzor Divalproex sodium [note 2] Depakote, Epival, Ergenyl Chrono Sodium valproate and valproic acid in 2.3:1 ratio: Depakine Chrono, Depakine Chronosphere, Epilim Chrono, Epilim Chronosphere
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
Generic Name Sales Q1 2014 Sales ($000) Change from Q4 2013 Company(ies) ... divalproex sodium: Valproate: 181,554: 0.00%: Generic: Epilepsy and bipolar disorder [15 ...
Valproic acid, and its derivatives such as sodium valproate and divalproex sodium, causes cognitive deficit in the child, with an increased dose causing decreased intelligence quotient and use is associated with adverse neurodevelopmental outcomes (cognitive and behavioral) in children.
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Valpromide (marketed as Depamide by Sanofi-Aventis) is a carboxamide derivative of valproic acid used in the treatment of epilepsy and some affective disorders.It is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself.
It is also marketed in the European Union under the brand name Inovelon. [6] It is available as a generic medication. [7] The mechanism of action of rufinamide is not fully understood. There is some evidence that rufinamide can modulate the gating of voltage-gated sodium channels, [8] [9] a common target for antiepileptic drugs. [10]