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Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity). It is more often applied to non-human animals than to humans. In general, it is preferred when large amounts of blood replacement fluids are needed or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection.
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).
After injection, a medication may be designed to be released slowly, called a depot injection, which can produce long-lasting effects. An injection necessarily causes a small puncture wound to the body, and thus may cause localized pain or infection. The occurrence of these side effects varies based on injection location, the substance injected ...
Intravenous administration, meaning injection into vein, is commonly used in most animals owing to its rapid speed to distribute the drug into the brain and its high reliability. [1] [2] Whilst there are alternatives like intraperitoneal injection which are less irritating, a larger dose of solution is required to euthanize the animals. [1] [2]
Examples of these studies include injection of bromodeoxyuridine for proliferation tracing, Apelin-13 for cerebral ischemia, and α-interferon for its antiviral and antibiotic properties. ICV injection of bromodeoxyuridine (BrdU) has been used to determine the effectiveness of this injection method compared to intraperitoneal administration.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.
Intraperitoneal antibiotics are preferred to intravenous as they have a greater effect at the area of infection, unless sepsis is present, in which case intravenous antibiotics are indicated. [18] The peritoneal dialysis catheter may have to be removed if the infection does not resolve with antibiotics, and it is recommended that the PD ...
Veterinarians use intrathoracic injections to deliver medication into the thoracic cavity, or the chest region, and right near the surface of the heart. [28] Intraperitoneal injection is the method of injection where the needle is inserted into the peritoneal cavity, or a region in the lower abdomen.