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[2] [3] Symptoms of this infection vary greatly, but the disease affects primarily the lungs. [4] Occasionally, other organs are affected; called disseminated histoplasmosis, it can be fatal if left untreated. H. capsulatum is found in soil, often associated with decaying bat guano or bird droppings. Disruption of soil from excavation or ...
Hantavirus pulmonary syndrome (HPS), also called hantavirus cardiopulmonary syndrome (HCPS), is a severe respiratory disease caused by hantaviruses. The main features of illness are microvascular leakage and acute respiratory distress syndrome. Symptoms occur anywhere from 1 to 8 weeks after exposure to the virus and come in three distinct phases.
Transmission electron micrograph of the Sin Nombre virus, the virus responsible for the outbreak. The spherical particles are virus bodies (virions). The 1993 Four Corners hantavirus outbreak was an outbreak of hantavirus disease that occurred in the Four Corners region of the US states in Arizona, Colorado, and New Mexico.
However, when the lungs are involved, the risk of death increases to the range of 50–70%. [8] It is estimated that one million severe cases of leptospirosis in humans occur every year, causing about 58,900 deaths. [11] The disease is most common in tropical areas of the world but may occur anywhere. [7] Outbreaks may arise after heavy ...
In 1996, the marsh rice rat, which is seen in marshes in the southeast and mountain streams in the northeast, was identified as the natural reservoir of the virus. Due to the virus being first identified in Louisiana, this indicated the virus to be widespread throughout the Southeastern United States. This hantavirus disease is known as a ...
Rats, like many other species, can be hosts to a number of diseases, and are known natural reservoirs of several zoonoses (infectious diseases able to be transmitted between species). Both Black rats and Brown rats are well known rodents that have had a close relationship with humans since the beginnings of civilization. They can also carry ...
The divergence in this domain indicates that, unlike SARS-CoV-2, the RaTG13 virus might not use angiotensin-converting enzyme 2 (ACE2) as its entry site into the cell. [18] Further, the S protein of RaTG13 virus lacks the furin cleavage motif RRAR↓S. [18] The binding affinity between RATG13 and hACE2 is lower than that between SARS-CoV-2 RBD ...
Bayou virus (BAYV) is a species of Orthohantavirus comprising enveloped and spherical viruses. It was first identified in 1993 in Louisiana and later confirmed by other investigators. BAYV was recognized as a distinct form of hantavirus disease, now known as hantavirus pulmonary syndrome (HPS).