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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
Adecatumumab (MT201) is a recombinant human IgG1 monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326), with the intent to trigger antibody-dependent cellular cytotoxicity.
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It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family. [3] Dasatinib was approved for medical use in the United States and in the European Union in 2006. [3] [2] It is on the World Health Organization's List of Essential Medicines. [4]
Isatuximab, sold under the brand name Sarclisa, is a monoclonal antibody (mAb) medication for the treatment of multiple myeloma. [6] [4]The most common side effects include neutropenia (low levels of neutrophils, a type of white blood cell), infusion reactions, pneumonia (infection of the lungs), upper respiratory tract infection (such as nose and throat infections), diarrhoea and bronchitis ...
Daratumumab [1] Janssen Biotech: multiple myeloma: Nivolumab [1] Bristol-Myers Squibb: advanced renal cell carcinoma: Elotuzumab [1] Bristol-Myers Squibb: multiple myeloma: Sebelipase alfa [1] Alexion Pharmaceuticals: lysosomal acid lipase deficiency: Alectinib [1] Hoffmann-La Roche: ALK-mutated NSCLC: Pembrolizumab [1] Merck Sharp & Dohme ...
Milatuzumab (or hLL1) is an anti-CD74 [1] humanized monoclonal antibody for the treatment of multiple myeloma non-Hodgkin's lymphoma and chronic lymphocytic leukemia. [2] [3]The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment of multiple myeloma.
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