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Stellate cells are neurons in the central nervous system, named for their star-like shape formed by dendritic processes radiating from the cell body. These cells play significant roles in various brain functions, including inhibition in the cerebellum and excitation in the cortex, and are involved in synaptic plasticity and neurovascular coupling.
Neuroinflammation is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. [5] Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. [6]
Astrocytes are the largest of the glial cells. They are stellate cells with many processes radiating from their cell bodies. Some of these processes end as perivascular endfeet on capillary walls. [42] The glia limitans of the cortex is made up of astrocyte endfeet processes that serve in part to contain the cells of the brain. [12]
Outside the brain, reelin is found in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells. [38] In the liver, reelin is localized in hepatic stellate cells. [39] The expression of reelin increases when the liver is damaged, and returns to normal following its repair. [40]
Satellite glial cells are a type of glia found in the peripheral nervous system, specifically in sensory, [2] sympathetic, and parasympathetic ganglia. [3] They compose the thin cellular sheaths that surround the individual neurons in these ganglia. In a SGC, the cell body is denoted by the region containing the single, relatively large nucleus ...
Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. [5] It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes [6] and ependymal cells during development. [7]
These cells are some of the largest neurons in the human brain (Betz cells being the largest), [5] with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like dominos stacked one in
The authors of this study found that TREM2 is expressed by Kupfer cells and hepatic stellate cells, indicating that TREM2 might downregulate inflammation. [56] Expression was also increased in liver tissues from patients with cirrhosis. [56]