Search results
Results From The WOW.Com Content Network
Renin cleaves a decapeptide from angiotensinogen, a globular protein. The decapeptide is known as angiotensin I . Angiotensin I is then converted to an octapeptide , angiotensin II by angiotensin-converting enzyme (ACE), [ 9 ] which is thought to be found mainly in endothelial cells of the capillaries throughout the body, within the lungs and ...
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin-angiotensin-aldosterone system (RAAS)—also known as the renin-angiotensin-aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial ...
Angiotensinogen is also known as renin substrate. It is cleaved at the N-terminus by renin to result in angiotensin I, which will later be modified to become angiotensin II. [8] [10] This peptide is 485 amino acids long, and 10 N-terminus amino acids are cleaved when renin acts on it. [8] The first 12 amino acids are the most important for ...
Prorenin (/ p r ə ˈ r iː n ɪ n / [1]) is a protein that constitutes a precursor for renin, [2] the hormone that activates the renin–angiotensin system, which serves to raise blood pressure. Prorenin is converted into renin by the juxtaglomerular cells , which are specialised smooth muscle cells present mainly in the afferent, but also the ...
Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood ...
Relaxation of muscle and ligament tissues in female humans as preparation for menstruation. Anticipatory release for ductus deferens in males. Cardiac vasodilator. 56 Renin: Peptide: Kidney: Juxtaglomerular cells: Activates the renin–angiotensin system by producing angiotensin I of angiotensinogen: 57 Secretin: SCT Peptide: duodenum: S cell ...
The renin receptor binds renin and prorenin.Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. [8]This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis.
Once in the bloodstream, renin converts angiotensinogen to angiotensin I. Angiotensin I is further cleaved by the angiotensin-converting enzyme to angiotensin II, which is a potent vasoconstrictor that increases blood pressure. [144] In addition to angiotensin II, other biologically active substances can be formed in mammals.