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Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that affect the patient's immune system.
Secondary or acquired immune deficiencies are caused by something outside the body such as a virus or immune suppressing drugs. [ 6 ] Primary immune diseases are at risk to an increased susceptibility to, and often recurrent ear infections, pneumonia , bronchitis , sinusitis or skin infections.
Treatment for combined immunodeficiencies with defects in antibody production primarily consists of immunoglobulin replacement therapy. [1] Susceptibility to infections is an important feature of combined immunodeficiencies and influences patients' clinical evolution; as a result, antimicrobial prophylaxis is frequently used to prevent ...
CVID is the most common form of primary immunodeficiency. SCID is considered a medical emergency and suspected cases require immediate specialist center referral for diagnosis and treatment. It is more often that hypogammaglobulinemia develops as a result of another condition, which are called secondary or acquired immune deficiencies.
The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on population. They are associated with increased vulnerability to infection, but can be difficult to detect (or asymptomatic) in the absence of infection.
Severe Combined Immune Deficiency; Other names: Alymphocytosis, Glanzmann–Riniker syndrome, Severe mixed immunodeficiency syndrome, and Thymic alymphoplasia [1] David Vetter, a child born in 1971 with severe combined immunodeficiency (SCID). Specialty: Immunology Treatment: Bone marrow transplantation and prophylaxis against infection: Medication