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In some cases, WSO is a misdiagnosis of "keratins granulations" which are not a fungus, but a reaction to nail polish that can cause the nails to have a chalky white appearance. A laboratory test should be performed to confirm. [19] Proximal subungual onychomycosis is fungal penetration of the newly formed nail plate through the proximal nail fold.
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Candidal onychomycosis is an infection of the nail plate by fungus caused by Candida. [1]: 305 In one study Candida parapsilosis was the most common species; Candida albicans is also a common agent. [2]
Azoles are predominantly fungistatic which inhibit the growth of the fungus instead of killing the fungus. These drugs target the ergosterol biosynthetic pathway by inhibiting the C-14 α-demethylase, a cytochrome P450 enzyme, thus preventing the demethylation of lanosterol to ergosterol which is an essential component of the fungal cell membrane.
Onycholysis is a common medical condition characterized by the painless detachment of the nail from the nail bed, usually starting at the tip and/or sides. [1] On the hands, it occurs particularly on the ring finger but can occur on any of the fingernails. It may also happen to toenails. Onycholysis can occur in many conditions, including ...