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The Bova Group sells GS-441524, a medication compound that can help treat FIP. However, the drug wasn’t available in the U.S. ... New Jersey-based Stokes Pharmacy noted that the Bova Group’s ...
Bova, a veterinary pharmaceuticals company based in the U.K. and Australia, began selling GS-441524, a drug compound to treat FIP, in 2021 — but the drug was not available for sale in the United ...
Fox News reports that "Stokes Pharmacy has formed an exclusive partnership with the Bova Group to offer a U.S.-made compounded oral treatment for feline infectious ... began selling GS-441524, a ...
GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir , and has a half-life of around 24 hours in human patients.
In the fall of 2024, GS-441524 became commercially available through at least one compounding pharmacy. In several countries oral GS-441524 tablets (and its injectable prodrug remdesivir) became legally available to vets for the treatment of FIP in cats, for example in Australia, [22] the Netherlands, [23] [a] and the United Kingdom (since ...
Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high risk patients. [ 1 ] [ 2 ] The purpose of the isobutyric ester modification on obeldesivir is to improve the oral bioavailability of the parent nucleoside, GS ...
Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. [23] The most common side effect in healthy volunteers is raised blood levels of liver enzymes. [13]
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