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Phyllodes tumors are part of a group of breast diseases called cellular fibroepithelial lesions. [8] This term incorporates a spectrum of diseases ranging from a benign fibroadenoma to a malignant phyllodes tumor, with numerous variants in between. [14] They are classified by ICD-O, not by MeSH. [14]
A fibroepithelial neoplasm (or tumor) is a biphasic tumor. They consist of epithelial tissue, and stromal or mesenchymal tissue. They may be benign or malignant. [1] Examples include: Brenner tumor of the ovary; Fibroadenoma of the breast; Phyllodes tumor of the breast; Sometimes fibroepithelial polyps (FEPs) of the vulva may be misdiagnosed as ...
A hematoxylin and eosin stained slide show a cellular stroma with an innumerable psammoatoid calcifications. By microscopic evaluation, the tumors are composed of a variably cellular stroma make up of spindled to stellate fibroblast-like cells. Within this stroma, are numerous small, rounded, mineralized collagenous ossicles and immature osteoid.
A peripheral ossifying fibroma, also known as ossifying fibrous epulis, is “a gingival nodule which is composed of a cellular fibroblastic connective tissue stroma which is associated with the formation of randomly dispersed foci of mineralised products, which consists of bone, cementum-like tissue, or a dystrophic calcification.
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ , for example in the uterine mucosa ( endometrium ), prostate , bone marrow , lymph node and the ovary .
Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen. [7] Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses. [8]
Less commonly. cellular angiofibromas have occurred in various other superficial soft tissue areas throughout the body. [26] These tumors are edematous (i.e. abnormally swollen with fluid), highly vascular, spindle-shaped cell lesions with a variable amount of fibrous stroma. [25]
Stromal cells within the tumor microenvironment represent an important cellular component in cancer development, influencing tumor metabolism, growth, metastasis, immune evasion, and resistance to chemotherapy. These cells can originate from neighboring non-cancerous stromal cells or undergo transdifferentiation from tumor cells. Stromal cells ...