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Phenylpropanolamine is not substantially metabolized. [7] [5] It also does not undergo significant first-pass metabolism. [7] Only about 3 to 4% of an oral dose of phenylpropanolamine is metabolized. [5] Metabolites include hippuric acid (via oxidative deamination of the side chain) and 4-hydroxynorephedrine (via para-hydroxylation).
phenylpropanolamine – controls urinary incontinence in dogs phenytoin/pentobarbital – animal euthanasia product containing phenytoin and pentobarbital pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs
Additionally, acepromazine is used as a vasodilator in the treatment of laminitis, where an oral dose equivalent to "mild sedation" is commonly used, although the dose used is highly dependent on the treating veterinarian. While it is shown to elicit vasodilation in the distal limb, evidence showing its efficacy at increasing perfusion in the ...
Dosage of Apoquel for dogs. The following is a guideline for the typical use of the drug in dogs and must not replace your veterinarian’s advice for your individual pet.
Shannon and co-workers confirmed and extended some of Tainter's studies. After administering phenylethanolamine to dogs intravenously, these investigators observed that 10–30 mg/kg of the drug increased pupil diameter, and decreased body temperature; a dose of 10 or 17.5 mg/kg decreased heart rate, but a 30 mg/kg dose caused it to increase.
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]