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Antiphospholipid syndrome, or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies. APS can lead to blood clots ( thrombosis ) in both arteries and veins , pregnancy-related complications , and other symptoms like low platelets, kidney disease , heart disease , and rash .
An increase in the prevalence of antiphospholipid antibodies (known as antiphospholipid syndrome) can be found in many recurrent miscarriage patients. However, there is no evidence that the increase in antiphospholipid antibodies harms the pregnancy, but is thought to be indicative of immune dysfunction and proinflammatory responses in regards ...
In a suspected antiphospholipid syndrome, lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two positive blood test results spaced at least three months apart that detect at ...
Pregnancy outcome appears to be worse in those with lupus whose disease flares up during pregnancy. [7] Miscarriages in the first trimester appear either to have no known cause or to be associated with signs of active lupus. [8] Later losses appear to occur primarily due to the antiphospholipid syndrome, in spite of treatment with heparin and ...
Antiphospholipid syndrome: The antiphospholipid syndrome is an autoimmune disease that is a common cause of recurrent pregnancy loss. [ 34 ] [ 15 ] Around 15% of the women who have recurrent miscarriages have high levels of antiphospholipid antibodies. [ 34 ]
Antiphospholipid antibody syndrome [116] Hyperemesis gravidarum [117] Acute fatty liver of pregnancy [118] Gestational diabetes [100] Hemoglobinopathies [119] Postpartum thyroiditis [120] Postpartum depression [121] Hyperpigmentation [122] Hair growth changes [100] Herpes gestationitis [123] Pruritic urticarial papaules of pregnancy [123]
Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a rare autoimmune disease in which widespread, intravascular clotting causes multi-organ failure. [1] The syndrome is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with phospholipids .
Among other causes of hypercoagulability, Antiphospholipid syndrome has been associated with adverse pregnancy outcomes including recurrent miscarriage. [8] Deep vein thrombosis has an incidence of one in 1,000 to 2,000 pregnancies in the United States, [ 2 ] and is the second most common cause of maternal death in developed countries after ...