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Early trials in women with PCOS found that metformin helped give a small benefit in insulin sensitivity, reduced weight and helped restore periods, Dr. Ohri says. Because of this, metformin is ...
It therefore concluded that the benefit of metformin in the improvement of reproductive outcomes in women with PCOS is limited. [17] The ESHRE/ASRM-sponsored Consensus workshop does not recommend metformin for ovulation stimulation. [18] Subsequent randomized studies have confirmed the lack of evidence for adding metformin to clomiphene. [19]
Decreases in HbA1c (Hemoglobin A1c), an indicator of blood sugar over the previous 3 months. In PCOS, in addition to improved glucose markers, metformin can help to restore regular menstrual ...
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. [14] The syndrome is named after cysts which form on the ovaries of some women with this condition, though this is not a universal symptom, and not the underlying cause of the disorder.
[64] [65] Babies born to women treated with metformin have less visceral fat, and this may make them less prone to insulin resistance in later life. [66] The use of metformin for gestational diabetes resulted in smaller babies compared to treatment with insulin.
Some researchers are investigating how metformin, a common drug used to treat diabetes, may help prolong healthspan and lifespan. What evidence is there to support this notion?