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Early trials in women with PCOS found that metformin helped give a small benefit in insulin sensitivity, reduced weight and helped restore periods, Dr. Ohri says. Because of this, metformin is ...
Decreases in HbA1c (Hemoglobin A1c), an indicator of blood sugar over the previous 3 months. In PCOS, in addition to improved glucose markers, metformin can help to restore regular menstrual ...
Metformin shows may also help reduce the severity of diseases relating to insulin and glucose levels. This includes PCOS, certain tumor-related cancers, gestational diabetes and age-related diseases.
Insulin resistance in women with PCOS is typically treated with insulin-sensitizer drugs such as metformin. Metformin can help to decrease weight and androgen levels. [72] When combined with lifestyle modifications (changes in diet and exercise), it has been linked with lower body mass index and a reduction in menstrual problems. [72]
It therefore concluded that the benefit of metformin in the improvement of reproductive outcomes in women with PCOS is limited. [17] The ESHRE/ASRM-sponsored Consensus workshop does not recommend metformin for ovulation stimulation. [18] Subsequent randomized studies have confirmed the lack of evidence for adding metformin to clomiphene. [19]
[64] [65] Babies born to women treated with metformin have less visceral fat, and this may make them less prone to insulin resistance in later life. [66] The use of metformin for gestational diabetes resulted in smaller babies compared to treatment with insulin.
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