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The extracellular fluid, in particular the interstitial fluid, constitutes the body's internal environment that bathes all of the cells in the body. The ECF composition is therefore crucial for their normal functions, and is maintained by a number of homeostatic mechanisms involving negative feedback .
The main intravascular fluid in mammals is blood, a complex mixture with elements of a suspension (blood cells), colloid (), and solutes (glucose and ions).The blood represents both the intracellular compartment (the fluid inside the blood cells) and the extracellular compartment (the blood plasma).
The recommended daily amount of drinking water for humans varies. [1] It depends on activity, age, health, and environment.In the United States, the Adequate Intake for total water, based on median intakes, is 4.0 litres (141 imp fl oz; 135 US fl oz) per day for males older than 18, and 3.0 litres (106 imp fl oz; 101 US fl oz) per day for females over 18; it assumes about 80% from drink and 20 ...
Extracellular fluid (1/3 of body water) is fluid contained in areas outside of cells. For a 40-litre body, about 15 litres is extracellular, [9] which amounts to 37.5%. Plasma (1/5 of extracellular fluid). Of this 15 litres of extracellular fluid, plasma volume averages 3 litres, [9] or 20%. Interstitial fluid (4/5 of extracellular fluid)
The pH of the intracellular fluid and the extracellular fluid need to be maintained at a constant level. [2] The three dimensional structures of many extracellular proteins, such as the plasma proteins and membrane proteins of the body's cells, are very sensitive to the extracellular pH.
The total body of water is divided into fluid compartments, [1] between the intracellular fluid compartment (also called space, or volume) and the extracellular fluid (ECF) compartment (space, volume) in a two-to-one ratio: 28 (28–32) liters are inside cells and 14 (14–15) liters are outside cells.
Hypovolemia, also known as volume depletion or volume contraction, is a state of abnormally low extracellular fluid in the body. [1] This may be due to either a loss of both salt and water or a decrease in blood volume. [2] [3] Hypovolemia refers to the loss of extracellular fluid and should not be confused with dehydration. [4]
The majority of the sodium in the body stays in the extracellular fluid compartment. [27] This compartment consists of the fluid surrounding the cells and the fluid inside the blood vessels. ECF has a sodium concentration of approximately 140 mEq/L. [ 27 ] Because cell membranes are permeable to water but not sodium, the movement of water ...