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Ramipril is a pro-drug.The molecule must be hydrolyzed by an esterase at the OCH 2 CH 3 and form a carboxylate.This carboxylate then interacts with the positive Zn 2+ ion which is located at the active site of the ACE enzyme. [10]
A man taking a nap in the spring. Springtime lethargy is the state of fatigue, lowered energy, or depression associated with the onset of spring. Such a state may be caused by a normal reaction to warmer temperatures, or it may have a medical basis, such as allergies or reverse seasonal affective disorder. [1]
Diphenhydramine is also used off-label for its sedative properties, particularly by parents seeking to make their children sedated or sleep during long-haul flights. This use of diphenhydramine has been criticized for a number of reasons, ranging from ethical to safety concerns, [ 25 ] but also due to the risk of diphenhydramine's paradoxical ...
Sleep inertia is a physiological state of impaired cognitive and sensory-motor performance that is present immediately after awakening. It persists during the transition of sleep to wakefulness, where an individual will experience feelings of drowsiness, disorientation and a decline in motor dexterity.
Directed attention fatigue (DAF) is a neuro-psychological phenomenon that results from overuse of the brain's inhibitory attention mechanisms, which handle incoming distractions while maintaining focus on a specific task.
Turkey at Thanksgiving dinner doesn’t inherently make you sleepy. Other factors like alcohol, carb-heavy side dishes, and large portion sizes are more likely the culprit behind feeling tired ...
An oil painting of a young woman having a siesta, or an afternoon nap, which usually occurs after the mid-day meal.. Postprandial somnolence (colloquially known as food coma, after-dinner dip, or "the itis") is a normal state of drowsiness or lassitude following a meal.
Individuals with exploding head syndrome hear or experience loud imagined noises as they are falling asleep or are waking up, have a strong, often frightened emotional reaction to the sound, and do not report significant pain; around 10% of people also experience visual disturbances like perceiving visual static, lightning, or flashes of light.