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Fluoride or fluorine deficiency is a disorder which may cause increased dental caries [1] and possibly osteoporosis, [2] [3] due to a lack of fluoride in diet. [4] [5] Common dietary sources of fluoride include tea, grape juice, wine, raisins, some seafood, coffee, and tap water that has been fluoridated. [6]
Sodium fluoride (NaF) is an inorganic compound with the formula Na F.It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose.
[18 F]NaF is also taken-up by immature erythrocytes in the bone marrow, [21] which plays a role in fluoride kinetics. [22] The plasma protein binding of [18 F]NaF is negligible. [23] [18 F]NaF renal clearance is affected by diet [24] and pH level, [25] due to its re-absorption in the nephron, which is mediated by hydrogen fluoride. [26]
Benefits of fluoride toothpaste. The new research, published Thursday in the Cochrane Database of Systematic Reviews, included analyses of more than 157 studies that compared tooth decay in kids ...
Most patients with skeletal fluorosis show side effects from the high fluoride dose such as ruptures of the stomach lining and nausea. [4] Fluoride can also damage the parathyroid glands, leading to hyperparathyroidism, the uncontrolled secretion of parathyroid hormones. These hormones regulate calcium concentration in the body.
Dr. Dean's research on the fluoride-dental caries relationship, published in 1942, included 7,000 children from 21 cities in Colorado, Illinois, Indiana, and Ohio. The study concluded that the optimal amount of fluoride which minimized the risk of severe fluorosis but had positive benefits for tooth decay was 1 mg per day, per adult.