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2. Arachidonic acid - Wikipedia

   en.wikipedia.org/wiki/Arachidonic_acid

   The enzyme 12-lipoxygenase catalyzes oxidation of arachidonic acid to 12-hydroperoxyeicosatetraenoic acid (12-HPETE), which may then be metabolized to 12-hydroxyeicosatetraenoic acid (12-HETE) and to hepoxilins. [16] Arachidonic acid is also a precursor to anandamide. [17]

3. ALOX12 - Wikipedia

   en.wikipedia.org/wiki/ALOX12

   ALOX12, originally called arachidonate 12-lipoxygenase, was first characterized by the Nobel Laureate, Bengt I. Samuelsson, and his famed colleague, Mats Hamberg, in 1974 by showing that human platelets metabolize arachidonic acid not only by the well-known cyclooxygenase pathway into prostaglandins and 12-hydroxyheptadecatrienoic acid but also by a cyclooxygenase-independent pathway to 12(S ...

4. List of unsaturated fatty acids - Wikipedia

   en.wikipedia.org/.../List_of_unsaturated_fatty_acids

   Linoleic acid has 18 carbons, is contained in many vegetable oils, particularly semi-drying oils, and is a cis-9-cis-12-di-unsaturated fatty acid. C 17 H 31 CO 2 H, IUPAC organization name (9Z, 12Z)-octadeca-9,12-dienoic acid, numerical representation 18:2 (9,12), n-6, molecular weight 280.45, melting point −5 °C, specific gravity 0.902. CAS ...

5. 12-Hydroxyheptadecatrienoic acid - Wikipedia

   en.wikipedia.org/wiki/12-Hydroxyheptadecatrieno...

   12-Hydroxyheptadecatrienoic acid (also termed 12-HHT, 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid, or 12(S)-HHTrE) is a 17 carbon metabolite of the 20 carbon polyunsaturated fatty acid, arachidonic acid. 12-HHT is less ambiguously termed 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid to indicate the S stereoisomerism of its 12-hydroxyl ...

6. 12-Hydroxyeicosatetraenoic acid - Wikipedia

   en.wikipedia.org/.../12-Hydroxyeicosatetraenoic_acid

   12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z cis–trans configuration (Z=cis, E=trans) in its four double bonds.

7. Lipoxygenase - Wikipedia

   en.wikipedia.org/wiki/Lipoxygenase

   Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) differs from human ALOX15, which under standard assay conditions metabolizes arachidonic acid to 15-HpETE and 12-HpETE products in an 89 to 11 ratio, metabolizes arachidonic acid to 15-HpETE and 12-HpETE in a 1 to 6 ratio, i.e. its principal metabolite is 12-HpETE. Also, human ...

8. Eicosanoid - Wikipedia

   en.wikipedia.org/wiki/Eicosanoid

   The enzyme arachidonate 12-lipoxygenase (12-LO or ALOX12) metabolizes arachidonic acid to the S stereoisomer of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) which is rapidly reduced by cellular peroxidases to the S stereoisomer of 12-hydroxyeicosatetraenoic acid (12-HETE) or further metabolized to hepoxilins (Hx) such as HxA3 and HxB. [43] [44]

9. ALOX12B - Wikipedia

   en.wikipedia.org/wiki/ALOX12B

   ALOX12B oxygenates arachidonic acid by adding molecular oxygen (O 2) in the form of a hydroperoxyl (HO 2) residue to its 12th carbon thereby forming 12(R)-hydroperoxy-5Z,8Z,10E,14Z-icosatetraenoic acid (also termed 12(R)-HpETE or 12R-HpETE).