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  2. Fatty acid synthesis - Wikipedia

    en.wikipedia.org/wiki/Fatty_acid_synthesis

    In biochemistry, fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell. Most of the acetyl-CoA which is converted into fatty acids is derived from carbohydrates via the glycolytic pathway.

  3. Lipogenesis - Wikipedia

    en.wikipedia.org/wiki/Lipogenesis

    In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before ...

  4. Fatty acid synthase - Wikipedia

    en.wikipedia.org/wiki/Fatty_acid_synthase

    n/a n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two ...

  5. Fatty acid metabolism - Wikipedia

    en.wikipedia.org/wiki/Fatty_acid_metabolism

    Most fatty acids in human plasma are 16 or 18 carbon atoms long. CAT is inhibited by high concentrations of malonyl-CoA (the first committed step in fatty acid synthesis) in the cytoplasm. This means that fatty acid synthesis and fatty acid catabolism cannot occur simultaneously in any given cell.

  6. Fatty acid - Wikipedia

    en.wikipedia.org/wiki/Fatty_acid

    Fatty acids exhibit reactions like other carboxylic acids, i.e. they undergo esterification and acid-base reactions. Fatty acids do not show a great variation in their acidities, as indicated by their respective pK a. Nonanoic acid, for example, has a pK a of 4.96, being only slightly weaker than acetic acid (4.76).

  7. Fatty-acyl-CoA synthase - Wikipedia

    en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase

    The malfunction of the fatty acid synthesis pathway can result in cancer and obesity. However, the significance of fatty acid synthesis also make the fatty acid synthesis pathway a potential target for the search and study of anticancer and antibiotic drugs. [2] It has been found that in humans, fatty acid synthase, is overly expressed in ...

  8. Citrate–malate shuttle - Wikipedia

    en.wikipedia.org/wiki/Citrate–malate_shuttle

    The citrate-malate shuttle is a series of chemical reactions, commonly referred to as a biochemical cycle or system, that transports acetyl-CoA in the mitochondrial matrix across the inner and outer mitochondrial membranes for fatty acid synthesis. [1] Mitochondria are enclosed in a double membrane.

  9. Carnitine palmitoyltransferase I - Wikipedia

    en.wikipedia.org/wiki/Carnitine_palmitoyl...

    The carnitine palmitoyltransferase system is an essential step in the beta-oxidation of long chain fatty acids. This transfer system is necessary because, while fatty acids are activated (in the form of a thioester linkage to coenzyme A) on the outer mitochondrial membrane, the activated fatty acids must be oxidized within the mitochondrial matrix.