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Schizophrenia is a mental disorder [17] [7] ... Map of deficits in neural tissue throughout the human brain in a patient with schizophrenia. The most deficient areas ...
schizophrenia; Nigrostriatal pathway: The nigrostriatal pathway transmits dopaminergic neurons from the zona compacta of the substantia nigra [8] to the caudate nucleus and putamen. The substantia nigra is located in the midbrain, while both the caudate nucleus and putamen are located in the dorsal striatum. motor function; reward-related cognition
Further supporting this correlation between schizophrenia and the claustrum is that there is an increase in white matter volume entering the claustrum. [43] Inverse correlations between grey matter volume and severity of hallucinations in the context of auditory hallucinations of schizophrenia has been supported. [44]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
MRI studies have found a smaller brain volume and larger ventricles in people with schizophrenia – however researchers do not know if the shrinkage is from the schizophrenia or from the medication. [140] [141] The hippocampus and thalamus have been shown to be reduced in volume; and the volume of the globus pallidus is increased. Cortical ...
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