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Spleen produces all types of blood cells during fetal life; Production of opsonins, properdin, and tuftsin. Release of neutrophils following myocardial infarction. [19] Creation of red blood cells. While the bone marrow is the primary site of hematopoiesis in the adult, the spleen has important hematopoietic functions up until the fifth month ...
An image of the spleen in the human body. Also shows the red and white pulp regions. Splenocytes are spleen cells and consist of leukocytes like B and T cells, dendritic cells, and macrophages. [2] The spleen is split into red and white pulp regions with the marginal zone separating the two areas. The red pulp is involved with filtering blood ...
Acquired asplenia occurs for several reasons: . Following splenectomy due to splenic rupture from trauma or because of tumor; After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue. Specifically, the white pulp encompasses several areas with distinct functions:
The fibroelastic coat of the spleen invests the organ, and at the hilum is reflected inward upon the vessels in the form of sheaths. From these sheaths, as well as from the inner surface of the fibroelastic coat, numerous small fibrous bands, the trabeculae of the spleen (or splenic trabeculae), emerge from all directions; these uniting, constitute the frame-work of the spleen.
The red pulp of the spleen is composed of connective tissue known also as the cords of Billroth and many splenic sinusoids that are engorged with blood, giving it a red color. [1] [2] Its primary function is to filter the blood of antigens, microorganisms, and defective or worn-out red blood cells. [3]
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The spleen synthesizes antibodies in its white pulp and removes antibody-coated bacteria and antibody-coated blood cells by way of blood and lymph node circulation. The white pulp of the spleen provides immune function due to the lymphocytes that are housed there.