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  2. Lymphocyte-variant hypereosinophilia - Wikipedia

    en.wikipedia.org/wiki/Lymphocyte-variant_hyper...

    Reslizumab, a newly developed antibody directed against interleukin 5 that has been successfully used to treat 4 patients with the hypereosinophilic syndrome, may also be of use for lymphocyte-variant eosinophilia. [4] [5] [10] [11] Patients suffering minimal or no disease complications have gone untreated. [4]

  3. Hypereosinophilic syndrome - Wikipedia

    en.wikipedia.org/wiki/Hypereosinophilic_syndrome

    Depending on eosinophil target-organ infiltration, the clinical presentation of hypereosinophilic syndrome (HES) varies from patient to patient. [13] Individuals with myeloproliferative variant HES may be more likely to experience mucosal ulcerations involving the genitalia or airways, while patients with lymphocytic variant HES typically exhibit prominent skin symptoms such as urticarial ...

  4. Clonal hypereosinophilia - Wikipedia

    en.wikipedia.org/wiki/Clonal_hypereosinophilia

    Clonal hypereosinophilia, also termed primary hypereosinophilia or clonal eosinophilia, is a grouping of hematological disorders all of which are characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell that occupies the bone marrow, blood, and other tissues.

  5. Eosinophilia - Wikipedia

    en.wikipedia.org/wiki/Eosinophilia

    The idiopathic hypereosinophilic syndrome is a disorder characterized by hypereosiophilia that is associated with eosinophil-based tissue or organ damage. While almost any organ or tissue may be damaged, the lung, skin, heart, blood vessels, sinuses, kidneys, and brain are the most commonly affected. [7]

  6. Eosinophilic myocarditis - Wikipedia

    en.wikipedia.org/wiki/Eosinophilic_myocarditis

    Idiopathic hypereosinophilic syndrome and lymphocyte-variant hypereosinophilia: corticosteroids; for individuals with these hypereosinophilias that are refractory to or breakthrough corticosteroid therapy and individuals requiring corticosteroid-sparing therapy, recommended alternative drug therapies include hydroxyurea, Pegylated interferon-α ...

  7. Glaxo Gets FDA Nod for Nucala for Hypereosinophilic Syndrome

    www.aol.com/news/glaxo-gets-fda-nod-nucala...

    Glaxo's (GSK) Nucala becomes the first and only targeted biologic treatment to be approved for hypereosinophilic syndrome (HES), a rare disease caused by eosinophilic inflammation.

  8. Eosinophilic gastroenteritis - Wikipedia

    en.wikipedia.org/wiki/Eosinophilic_gastroenteritis

    Eosinophilic gastroenteritis (EG or EGE), also known as eosinophilic enteritis, [1] is a rare and heterogeneous condition characterized by patchy or diffuse eosinophilic infiltration of gastrointestinal (GI) tissue, first described by Kaijser in 1937.

  9. Acute eosinophilic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_eosinophilic_leukemia

    It can arise de novo or may develop in patients having the chronic form of a hypereosinophilic syndrome. Patients with acute eosinophilic leukemia have a propensity for developing bronchospasm as well as symptoms of the acute coronary syndrome and/or heart failure due to eosinophilic myocarditis and eosinophil-based endomyocardial fibrosis.