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The electron transport chain in the cell is the site of oxidative phosphorylation. The NADH and succinate generated in the citric acid cycle are oxidized, releasing the energy of O 2 to power the ATP synthase .
The electron transport chain in the mitochondrion is the site of oxidative phosphorylation in eukaryotes.It mediates the reaction between NADH or succinate generated in the citric acid cycle and oxygen to power ATP synthase.
The electron transport chain and enzymes in the matrix play a large role in the citric acid cycle and oxidative phosphorylation. The citric acid cycle produces NADH and FADH2 through oxidation that will be reduced in oxidative phosphorylation to produce ATP. [2] [3]
In eukaryotes, oxidative phosphorylation occurs in the mitochondrial cristae. It comprises the electron transport chain that establishes a proton gradient (chemiosmotic potential) across the boundary of the inner membrane by oxidizing the NADH produced from the Krebs cycle.
An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain.
For instance, the electron transport chain and oxidative phosphorylation all take place in the mitochondrial membrane. [4]: 73, 74 & 109 In contrast, glycolysis, pentose phosphate pathway, and fatty acid biosynthesis all occur in the cytosol of a cell. [5]: 441–442
Oxidative phosphorylation involves two processes — the electron transport chain and chemiosmosis — and occurs in mitochondria. Molecules such as glucose are metabolized to produce acetyl CoA as a fairly energy-rich intermediate.
The phosphate/oxygen ratio, or P/O ratio, refers to the amount of ATP produced from the movement of two electrons through a defined electron transport chain, terminated by reduction of an oxygen atom.