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During pregnancy, the enlarged abdomen and gravid uterus place additional strain on lumbar muscles and shift the pregnant woman's center of gravity. These postural compensations culminate in an increased load on both lumbar spinal musculature and the sacroiliac ligaments, manifesting as low back pain and/or pelvic girdle pain. [ 13 ]
In a review by Frazier et al., acute and chronic stress during pregnancy can diminish proper immunological activity crucial during pregnancy, and can possibly induce spontaneous abortion. [44] There is still a debate on whether the miscarriage is due to the depressive disease state or the anti-depressant medication.
During pregnancy the plasma volume increases by 40-50% and the red blood cell volume increases only by 20–30%. [22] These changes occur mostly in the second trimester and prior to 32 weeks gestation. [24] Due to dilution, the net result is a decrease in hematocrit or hemoglobin, which are measures of red blood cell concentration.
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Many symptoms and discomforts of pregnancy, such as nausea and tender breasts, appear in the first trimester. [56] During the second trimester, most women feel more energized and put on weight as the symptoms of morning sickness subside. They begin to feel regular fetal movements, which can become strong and even disruptive. [citation needed]
"It feels like pregnancy content is part of this initiation into contemporary parenting," says Rebecca Silber, who works in marketing in New Jersey and is pregnant with her second child.
Placenta previa is primarily diagnosed by ultrasound, either during a routine examination or following an episode of abnormal vaginal bleeding, often in the second trimester of pregnancy. Most diagnosis of placenta previa occurs during the second-trimester. [citation needed]
Preeclampsia is a hypertensive disorder that occurs during the second trimester (after the 20th week of pregnancy) resulting from a poorly perfused placenta. [9] The World Health Organization estimates that preeclampsia and eclampsia are responsible for about 14% of maternal deaths globally (around 50,000 to 75,000 deaths annually). [10]