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Doxycycline blocks protein production in apicoplast (an organelle) of P. falciparum—such blocking leads to two main effects: it disrupts the parasite's ability to produce fatty acids, which are essential for its growth, and it impairs the production of heme, a cofactor.
Most Apicomplexa contain a single ovoid shaped apicoplast that is found at the anterior of the invading parasitic cell. [4] The apicoplast is situated in close proximity to the cell's nucleus and often closely associated with a mitochondrion. The small plastid, only 0.15–1.5 μm in diameter, [4] is surrounded by four membranes. [8]
Doxycycline is also used as a prophylactic treatment for infection by Bacillus anthracis and is effective against Yersinia pestis, the infectious agent of bubonic plague. It is also used for malaria treatment and prophylaxis, as well as treating elephantitis filariasis . [ 10 ]
Example of a T-REx system controlling the expression of shRNA. Tetracycline-controlled transcriptional activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline).
Inhibits isoprenyl pyrophosphate, a molecule that carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane [13] Colistin: Coly-Mycin-S: Interact with the Gram-negative bacterial outer membrane and cytoplasmic membrane, displacing bacterial counterions, which destabilizes the outer membrane. Act like a ...
The 'apicoplast' is no longer capable of photosynthesis, but is an essential organelle, and a promising target for antiparasitic drug development. Some dinoflagellates and sea slugs , in particular of the genus Elysia , take up algae as food and keep the plastid of the digested alga to profit from the photosynthesis; after a while, the plastids ...
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