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In the kidney, the loop of Henle (English: / ˈ h ɛ n l i /) (or Henle's loop, Henle loop, [1] nephron loop [2] or its Latin counterpart ansa nephroni) is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule.
Within the nephron of the kidney, the descending limb of loop of Henle is the portion of the renal tubule constituting the first part of the loop of Henle. Physiology [ edit ]
The nephron is the minute or microscopic ... These components function as the filtration unit ... The primary role of the loop of Henle is to enable an organism to ...
Within the nephron of the kidney, the ascending limb of the loop of Henle is a segment of the heterogenous loop of Henle downstream of the descending limb, after the sharp bend of the loop. This part of the renal tubule is divided into a thin and thick ascending limb ; the thick portion is also known as the distal straight tubule , in contrast ...
This filtrate then flows along the length of the nephron, which is a tubular structure lined by a single layer of specialized cells and surrounded by capillaries. The major functions of these lining cells are the reabsorption of water and small molecules from the filtrate into the blood, and the secretion of wastes from the blood into the urine.
Pump: The Na + /K + /2Cl − transporter in the ascending limb of the loop of Henle helps to create a gradient by shifting Na + into the medullary interstitium. The thick ascending limb of the loop of Henle is the only part of the nephron lacking in aquaporin—a common transporter protein for water channels.
Both limbs of the loop of Henle are lined with the simple squamous epithelium. [2] Their main function is to regulate the levels of water and solutes in the primary urine . The basement membrane of the thin limb in humans has very uniform nodular thickenings that form a network that surrounds the tubule and acts as a support structure that is ...
The loop of Henle is the most prominent feature of the mammalian kidney. These loops provide the most efficient way to reabsorb water and create concentrated urine, allowing mammals to save water in their bodies. [138] After passing through the loop of Henle, the fluid becomes hypertonic relative to the blood plasma. [139]