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If there are no symptoms, but a paraprotein typical of myeloma and diagnostic bone marrow is present without end-organ damage, treatment is usually deferred or restricted to clinical trials. [105] Treatment for multiple myeloma is focused on decreasing the clonal plasma cell population and consequently decrease the symptoms of disease.
This treatment method is commonly linked with blood cancers like multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. It is also used in solid tumors such as germ cell tumors and certain high risk or recurrent breast cancers. Multiple myeloma, a type of plasma cell cancer [3] is an indication for HDC. Typically it follows stem cell ...
Common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. [10] Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. [10]
A bone marrow transplant, also called a stem cell transplant, restores blood stem cells for people who’ve undergone chemotherapy or radiation therapy for cancer, blood disorders, or autoimmune ...
MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. [4]
Bone marrow suppression, including Decreased white blood cell count causing increased risk of infection; Decreased platelet count causing increased risk of bleeding; Less common side effects include: Severe allergic reactions [7] Pulmonary fibrosis (scarring of lung tissue) including fatal outcomes (usually only with prolonged use) Hair loss