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Reverse triiodothyronine, also known as rT 3, is an isomer of triiodothyronine (T 3). Reverse T 3 is the third-most common iodothyronine the thyroid gland releases into the bloodstream, at 0.9%; tetraiodothyronine (levothyroxine, T 4 ) constitutes 90% and T 3 is 9%.
[22] [23] 3,5-T2 levels were also observed to correlate with concentrations of rT3 (reverse T3) [22] in patients with euthyroid sick syndrome. NTIS is a component of a complex endocrine adaptation process, so affected patients might also have hyperprolactinemia and elevated levels of corticosteroids (especially cortisol ) and growth hormone .
T 3 is the more metabolically active hormone produced from T 4.T 4 is deiodinated by three deiodinase enzymes to produce the more-active triiodothyronine: . Type I present in liver, kidney, thyroid, and (to a lesser extent) pituitary; it accounts for 80% of the deiodination of T 4.
Thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. [12]
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
Synthesis of T 2 from T 3, and from reverse T3. References This page was last edited on 24 June 2024, at 23:51 (UTC). ...