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HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of the same name belonging to the HERC family, which typically encodes large protein products with C-terminal HECT domains and one or more RCC1 -like (RLD) domains .
Some of the eye-color genes include OCA2 and HERC2. [9] [10] The earlier belief that blue eye color is a recessive trait has been shown to be incorrect, and the genetics of eye color are so complex that almost any parent-child combination of eye colors can occur. [11] [12] [13]
4948 18431 Ensembl ENSG00000104044 ENSG00000277361 ENSMUSG00000030450 UniProt Q04671 Q62052 RefSeq (mRNA) NM_000275 NM_001300984 NM_021879 RefSeq (protein) NP_000266 NP_001287913 NP_068679 Location (UCSC) Chr 15: 27.75 – 28.1 Mb Chr 7: 55.89 – 56.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse P protein, also known as melanocyte-specific transporter protein or pink-eyed ...
HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor.
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.
Once opened, compounded semaglutide typically lasts 28 days in the fridge. Compounded semaglutide, which contains the same active ingredient as Ozempic and Wegovy, is available from many ...