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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
In most cases pineal TRb is diagnosed before the age of 5, but after the diagnosis of retinoblastoma. Non-pineal TRb, however, is often diagnosed simultaneous with retinoblastoma. Prognosis of patients with trilateral retinoblastoma is dismal, only a few patients have survived more than 5 years after diagnosis; all survivors were diagnosed with ...
Free TV (Italy), an Italian regional television channel; FreeTV Australia, the industry body representing free-to-air Australian TV networks; Free TV Alliance, a collaboration between four European free digital satellite television broadcasters to promote free satellite TV; Free TV Networks, an American digital multicasting and video-on-demand ...
213464 Ensembl ENSG00000117222 ENSMUSG00000026439 UniProt Q15291 Q8BX09 RefSeq (mRNA) NM_001193272 NM_001193273 NM_005057 NM_172517 NM_001357486 NM_001357487 RefSeq (protein) NP_001180201 NP_001180202 NP_005048 NP_766105 NP_001344415 NP_001344416 Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.41 – 132.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma-binding ...
5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_002893 NM_009031 RefSeq (protein) NP_001185648 NP_002884 NP_033057 Location (UCSC) Chr X: 16.84 – 16.87 Mb Chr X: 161.54 – 161.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. Function ...
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. [ 5 ] [ 6 ] RBL2 is one of three retinoblastoma proteins encoded in the human genome (along with Rb and RBL1 ).