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THC-O-phosphate is a water-soluble organophosphate ester derivative of tetrahydrocannabinol (THC), which functions as a metabolic prodrug for THC itself.It was invented in 1978 in an attempt to get around the poor water solubility of THC and make it easier to inject for the purposes of animal research into its pharmacology and mechanism of action.
Tincture of cannabis, sometimes known as green dragon, is an alcoholic cannabis concentrate.The solubility of THC in ethanol is greater than 1 g/mL. [1]According to the European Medicines Agency (EMA) cannabis tinctures (tincturea) are a type of liquid cannabis extract obtained using ethanol, water, glycerol, propylene glycol and fatty oils as extraction solvents, depending on the type of ...
The alcohols extract undesirable water-soluble substances such as chlorophyll and sugars (which can be removed later by washing with water). Non-polar solvents such as benzene, chloroform and petroleum ether will not extract the water-soluble constituents of marijuana or hashish while still producing hash oil. In general, non-polar cannabis ...
A cannabis plant includes more than 400 different chemicals, of which about 70 are cannabinoids. [15] In comparison, typical government-approved medications contain only one or two chemicals. [15] The number of active chemicals in cannabis is one reason why treatment with cannabis is difficult to classify and study. [15]
Efforts to isolate the active ingredients in cannabis were made in the 19th century. [87] Cannabidiol was studied in 1940 from Minnesota wild hemp [87] and Egyptian Cannabis indica resin. [88] [89] The chemical formula of CBD was proposed from a method for isolating it from wild hemp. [87] Its structure and stereochemistry were determined in ...
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [ 34 ] , followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo . [ 35 ]
Hemp seed oil is manufactured from varieties of Cannabis sativa that do not contain significant amounts of tetrahydrocannabinol (THC), the principal psychoactive element present in the cannabis plant. This manufacturing process typically includes cleaning the seed to 99.99% before pressing the oil.
Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), an active component of cannabis. [1]THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked or cooked into cannabis edibles.