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CD1–restricted T cells produce T H 1, IFN-γ and TNF-α cytokines and are cytolytic. They can induce TNF-α dependent dentritic cells maturation. Many group 1 CD1–restricted T cells are autoreactive, and autoreactivity is enhanced by stimulation through pattern recognition receptors . CD1a-restricted T cells are among the most frequent self ...
CD1a self-reactive T cells were found in the blood of healthy individuals. [8] These cells express skin-homing receptors and produce interleukin 22 after binding CD1a on Langerhans cells. CD1a binds many endogenous lipids found in skin-oil and is able to activate T-cells even with ligands that lack a hydrophilic part, e.g. squalene. [2] [3]
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene. [3] This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of ...
The purpose of thymocyte development is to produce mature T cells with a diverse array of functional T cell receptors, through the process of TCR gene rearrangement. Unlike most genes, which have a stable sequence in each cell which expresses them, the T cell receptor is made up of a series of alternative gene fragments. In order to create a ...
The FDA recalled 60 doughnut products, totaling more than 2 million cases, for potential listeria contamination. The doughnuts were sold throughout the U.S. and Canada.
CD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. CD1b: T-cell surface glycoprotein CD1b.
Multiple major wildfires are raging around Los Angeles, forcing tens of thousands of people to evacuate, threatening thousands of structures and leading to a still unknown number of deaths and ...