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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
The condition can cause localized pain, discoloration (paleness), and sensations of cold and/or numbness. When exposed to cold temperatures, the blood supply to the fingers or toes, and in some cases the nose or earlobes, is markedly reduced; the skin turns pale or white (called pallor) and becomes cold and numb.
Peripheral neuropathy may first be considered when an individual reports symptoms of numbness, tingling, and pain in feet. After ruling out a lesion in the central nervous system as a cause, a diagnosis may be made on the basis of symptoms, laboratory and additional testing, clinical history, and a detailed examination.
Along with feeling cold, if you notice “your hands have significant color change, numbness, weakness or pain, it could be from an underlying vascular disease, neurologic problems or Raynaud’s ...
Chilblains of the feet, caused by excessive exposure to cold and humidity. Dermatitis in extremities (toes, fingers, earlobes, nose, etc), including: Burning and itching sensations; Throbbing pain; Skin discoloration (red to dark blue) with erythema (blanchable redness) Blistering of affected area; Ulceration (in severe cases only)
Frostbite is a skin injury that occurs when someone is exposed to extremely low temperatures, causing the freezing of the skin or other tissues, [1] commonly affecting the fingers, toes, nose, ears, cheeks and chin areas. [6] Most often, frostbite occurs in the hands and feet.