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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Human penis was previously believed under TCM to stop bleeding, and as with other TCM medicines, the basis for belief in its therapeutic effects is anecdotal and not based on the scientific method; Li Shizhen, author of the greatest pharmacological work in pre-modern China, the Bencao Gangmu, objected to use of human penis, but cited the ...
Herbivores can avoid plant defenses by eating plants selectively in space and time. For the winter moth, feeding on oak leaves early in the season maximized the amount of protein and nutrients available to the moth, while minimizing the amount of tannins produced by the tree. [16] Herbivores can also spatially avoid plant defenses.
Many prey animals, and to defend against seed predation also seeds of plants, [55] make use of poisonous chemicals for self-defence. [51] [56] These may be concentrated in surface structures such as spines or glands, giving an attacker a taste of the chemicals before it actually bites or swallows the prey animal: many toxins are bitter-tasting ...
Cats and humans evolutionarily diverged from a common ancestor (boreoeutherian ancestor) approximately 80 million years ago, accumulating only 10–12 chromosomal translocations. [71] The order of eight genes on the cats' Y chromosome closely resembles that in humans. [72] Genes on X chromosomes of cats and humans are arranged in a similar way ...
In pharmacology, potency or biological potency [1] is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. [2]