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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Cats and humans evolutionarily diverged from a common ancestor (boreoeutherian ancestor) approximately 80 million years ago, accumulating only 10–12 chromosomal translocations. [71] The order of eight genes on the cats' Y chromosome closely resembles that in humans. [72] Genes on X chromosomes of cats and humans are arranged in a similar way ...
This is a list of plant species that, when consumed by humans, are known or suspected to produce psychoactive effects: changes in nervous system function that alter perception, mood, consciousness, cognition or behavior. Many of these plants are used intentionally as psychoactive drugs, for
In pharmacology, potency or biological potency [1] is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. [2]
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Additionally, they collaborate, play, and share resources. When cats communicate with humans, they do so to get what they need or want, such as food, water, attention, or play. As such, cat communication methods have been significantly altered by domestication. [1] Studies have shown that domestic cats tend to meow much more than feral cats. [2]
Cypermethrin is very toxic to cats which cannot tolerate the therapeutic doses for dogs. [6] This is associated with UGT1A6 deficiency in cats, the enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses.
Heliotropium / ˌ h iː l i ə ˈ t r oʊ p i əm,-l i oʊ-/ [3] is a genus of flowering plants traditionally included in the family Boraginaceae s.l., but placed in the family Heliotropiaceae within the Boraginales order, by the Boraginales Working Group.. [4]