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Ruxolitinib (sold under the brand names Jakafi and Jakavi among others, and as Opzelura in cream form) is a medication used for the treatment of intermediate or high-risk myelofibrosis, [6] a type of myeloproliferative neoplasm that affects the bone marrow; [11] [12] polycythemia vera, when there has been an inadequate response to or intolerance of hydroxyurea; [6] [13] and steroid-refractory ...
[3] [4] In MANIFEST-2, a phase three, randomized, blinded study compares pelabresib and ruxolitinib with placebo and ruxolitinib in myelofibrosis patients that have not been previously treated with Janus kinase inhibitors (JAKi). [5] [6]
"Deuruxolitinib (Code C175770)".NCI Thesaurus. "Deuruxolitinib Phosphate (Code C175771)".NCI Thesaurus.; Clinical trial number NCT04518995 for "Study to Evaluate the Efficacy and Safety of CTP-543 in Adults With Moderate to Severe Alopecia Areata (THRIVE-AA1) (THRIVE-AA1)" at ClinicalTrials.gov
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800-290-4726 more ways to reach us. Sign in. Mail. 24/7 Help. ... February 6, 2024 at 3:40 AM ... when used in combination with ruxolitinib, a class of drugs called JAK inhibitors. ...
The first JAK inhibitor to reach clinical trials was tofacitinib. Tofacitinib is a specific inhibitor of JAK3 ( IC 50 = 2 nM) thereby blocking the activity of IL-2 , IL-4 , IL-15 and IL-21 . Hence T h 2 cell differentiation is blocked and therefore tofacitinib is effective in treating allergic diseases.
Participants with an 11q23 partial tandem duplication were excluded. [3] Revumenib was administered until disease progression, unacceptable toxicity, failure to achieve morphological leukemia-free state by four cycles of treatment, or hematopoietic stem cell transplantation.