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Faropenem is closely related, but it is a penem, not a carbapenem. [43] Antimicrobial resistance. NDM-1 is an enzyme that introduces bacterial resistance to carbapenem antibiotics via hydrolysis of the carbapenem backbone, thereby inactivating its ability to inhibit cell wall synthesis.
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
In general, carbapenem, a β-lactam antibiotic, targets cells by inhibiting transpeptidases (penicillin-binding proteins). This prevents synthesis of peptidoglycan, a necessary structural component, leading to cell lysis. Resistance to carbapenem among Enterobacteriaceae and other gram-negative bacteria can be acquired through several mechanisms.
Ceftazidime (Unlike most third-generation agents, ceftazidime is active against Pseudomonas aeruginosa, but less active against Staphylococci and Streptococci compare to other 3rd generation of cephalosporins) Fortaz, Ceptaz: Ceftibuten: Cedax: Ceftizoxime: Moxalactam: Ceftriaxone (IV and IM, not orally, effective also for syphilis and ...
Chemical Agents Warning Properties Latency Period Initial Symptoms Blister Agents Lewisite Gas: colorless Odor: geraniums Seconds to minutes
A carbapenam is a β-lactam compound that is a saturated carbapenem. [1] They exist primarily as biosynthetic intermediates on the way to the carbapenem antibiotics. Structure of (3S,5R)-carbapenam-3-carboxylic acid
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Imipenem, a carbapenem. Imipenem has a sulfur atom that is not in the pentacyclic ring. Benzylpenicillin, a penicillin. The double bond is absent in the pentacyclic ring. Penem molecules do not occur naturally, and production of penems is an entirely synthetic process.