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Clonidine, sold under the brand name Catapres among others, is an α 2A-adrenergic receptor agonist [12] medication used to treat high blood pressure, ADHD, drug withdrawal (e.g., alcohol, opioids, or nicotine), menopausal flushing, diarrhea, spasticity, and certain pain conditions. [13]
Clonidine and other imidazoline compounds have also been shown to reduce muscle spasms by their central nervous system activity. Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. [26]
Medications such as clonidine and dexmedetomidine target pre-synaptic auto receptors, therefore leading to an overall decrease in norepinephrine which clinically can cause effects such as sedation, analgesia, lowering of blood pressure and bradycardia. There is also low quality evidence that they can reduce shivering post operatively.
The study analyzed records of more than 125,000 adults who began taking the GLP-1 drugs liraglutide, semaglutide, or tirzepatide between January 2018 and December 2023.
Rebecca Jeanne Riley (April 11, 2002 – December 13, 2006) was a four-year-old girl from Massachusetts. In December 2006, Riley's parents gave Riley—who had been diagnosed with attention-deficit hyperactivity disorder and pediatric bipolar disorder between two and three years old—a lethal dose of clonidine.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
An old drug has taken on new popularity — and it has doctors concerned. “We walk into the president's chambers (at the fraternity) … and there’s three dudes carrying, like, Butane tanks ...
In general, the simultaneous use of multiple drugs should be carefully monitored by a qualified individual such as board certified and licensed medical doctor, either an MD or DO. Close association between prescribing physicians and pharmacies, along with the computerization of prescriptions and patients' medical histories, aim to avoid the ...