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An inotrope [help 1] or inotropic is a drug or any substance that alters the force or energy of muscular contractions.
Cardiotonic agents, also known as cardiac inotropes or stimulants, have a positive impact on the myocardium (muscular layer of the heart) by enhancing its contractility. . Unlike general inotropes, these agents exhibit a higher level of specificity as they selectively target the myocar
The antagonism of β 1 inotropic and chronotropic effects decreases the amount of work the heart must perform. It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their activity can slow the deterioration of cardiac function.
Pimobendan is a positive inotrope, and its main function is to increase myocardial contractility. It sensitizes and increases the binding efficiency of cardiac troponin in the myofibril to the calcium ions that are already present in systole. In normal hearts it increases the consumption of oxygen and energy to the same degree as dobutamine but ...
Uthlaut said many soldiers come in with “some level of addiction to their phones” and “don't know how to interact with one another because they're so used to being in digital-type forums.”
A fast-spreading wildfire that erupted this week northwest of Los Angeles roared from nothing to nearly 10,000 acres − in a matter of hours.