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Pulmonary surfactant is a surface-active complex of phospholipids and ... identified the function of the pulmonary surfactant in increasing the compliance of the ...
In molecular biology, Pulmonary surfactant protein D (SP-D) is a protein domain predominantly found in lung surfactant. This protein plays a special role; its primary task is to act as a defence protein against any pathogens that may invade the lung. It also plays a role in lubricating the lung and preventing it from collapse.
20390 Ensembl ENSG00000133661 ENSMUSG00000021795 UniProt P35247 P50404 RefSeq (mRNA) NM_003019 NM_009160 RefSeq (protein) NP_003010 NP_033186 Location (UCSC) Chr 10: 79.94 – 79.98 Mb Chr 14: 40.89 – 40.91 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin ...
These mutations cause total absence or loss-of-function of SP-B and lead to imbalance in surfactant homeostasis. Since SP-B has a major role in surfactant biogenesis and spreading of surfactant and lipid layer, any disruption to existence of SP-B results in ineffective respiration and lethal pulmonary conditions at birth. [5]
The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. Alveolar sac region of the lung - TEM. SP-A1 is a member of a subfamily of C-type lectins called collectins. Together with SP-A2, they are the most abundant proteins of pulmonary surfactant.
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid (and a lecithin) consisting of two C 16 palmitic acid groups attached to a phosphatidylcholine head-group.. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing.
SP-B is a critical protein for lung function, and is found in the context of pulmonary surfactant. Understanding surfactant is important to gaining a full understanding of SP-B. Surfactant is a mixture of lipids and proteins that coats the inside of alveoli and is essential for life due to its key role in preventing alveolar collapse at low ...
Phosphatidylglycerol is a glycerophospholipid found in pulmonary surfactant [1] and in the plasma membrane where it directly activates lipid-gated ion channels. The general structure of phosphatidylglycerol consists of a L-glycerol 3-phosphate backbone ester-bonded to either saturated or unsaturated fatty acids on carbons 1 and 2.