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6% (< 60 years old), 20% (> 60 years old) [ 4 ] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [ 5 ] Symptoms can vary from none to severe. [ 1 ] Mild deficiency may have few or absent symptoms. [ 1 ]
One of the superpowers of vitamin B12 is that it is the only water-soluble vitamin that can be stored in the human body, Kitchens points out, and it can remain stored in the liver for several years.
Frequency. 1 per 1000 people [8] Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [5] The most common initial symptoms are feeling tired and weak. [4]
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation. This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]
Wernicke-Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and alcoholic Korsakoff syndrome (AKS [clarification needed]). Due to the close relationship between these two disorders, people with either are usually diagnosed with WKS as a single syndrome. It mainly causes vision changes, ataxia and impaired memory.
Metformin can also cause a vitamin B12 deficiency, which may be linked with anemia. ... Before taking metformin, let your doctor know if you have any medical conditions like kidney or liver ...