Search results
Results From The WOW.Com Content Network
GDP remains bound to the inactive GTPase until a GEF binds and stimulates its release. [3] The localization of GEFs can determine where in the cell a particular GTPase will be active. For example, the Ran GEF, RCC1, is present in the nucleus while the Ran GAP is present in the cytosol, modulating nuclear import and export of proteins. [8]
Reaction of GeF 4 with fluoride sources produces GeF 5 − anions with octahedral coordination around Ge atom due to polymerization. [6] The structural characterization of a discrete trigonal bipyramidal GeF 5 − anion was achieved by a "naked" fluoride reagent 1,3-bis(2,6-diisopropylphenyl)imidazolium fluoride.
Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the RAPGEF4 gene. [ 5 ] [ 6 ] [ 7 ]
The inactive form of GTPases (GDP-form) are activated by a class of proteins called Guanosine nucleotide exchange factors (GEFs). GEFs catalyse nucleotide exchange by encouraging the release of GDP from the small GTPase (by displacement of the small GTPase-associated Mg 2+ ion) and GDP's replacement by GTP (which is in at least a 10-fold excess within the cell) .
The large G proteins, for example, are involved in transduction of signaling from the G protein-coupled receptor for a variety of signaling processes like hormonal signaling, [2] and small G proteins are involved in processes like cellular trafficking and cell cycling. [3] GAP's role in this function is to turn the G protein's activity off.
Germanium tetrafluoride, GeF 4, a colorless molecular gas Index of chemical compounds with the same name This set index article lists chemical compounds articles associated with the same name.
[4] RGS domains in the G protein-coupled receptor kinases are able to bind to Gq family α-subunits, but do not accelerate their GTP hydrolysis. Instead, GRKs appear to reduce Gq signaling by sequestering the active α-subunits away from effectors such as phospholipase C-β.
For example, in adipose tissues, two different G-proteins with interchangeable beta-gamma complexes are used to activate or inhibit adenylyl cyclase. The alpha subunit of a stimulatory G protein activated by receptors for stimulatory hormones could stimulate adenylyl cyclase, which activates cAMP used for downstream signal cascades.