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The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na + /K +-ATPase, Na + /K + pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na + /K +-ATPase enzyme is active (i.e. it ...
Active transport is essential for various physiological processes, such as nutrient uptake, hormone secretion, and nig impulse transmission. For example, the sodium-potassium pump uses ATP to pump sodium ions out of the cell and potassium ions into the cell, maintaining a concentration gradient essential for cellular function. Active transport ...
11928 Ensembl ENSG00000163399 ENSMUSG00000033161 UniProt P05023 Q5TC02 Q8VDN2 RefSeq (mRNA) NM_000701 NM_001001586 NM_001160233 NM_001160234 NM_144900 RefSeq (protein) NP_000692 NP_001153705 NP_001153706 NP_659149 Location (UCSC) Chr 1: 116.37 – 116.41 Mb Chr 3: 101.48 – 101.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein domain Gastric H + /K + -ATPase, N terminal ...
Diffusion vs. Transport. In biology, an ion transporter is a transmembrane protein that moves ions (or other small molecules) across a biological membrane to accomplish many different biological functions, including cellular communication, maintaining homeostasis, energy production, etc. [1] There are different types of transporters including pumps, uniporters, antiporters, and symporters.
A loss of function mutation of NKCC2 produces Bartter syndrome, an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis with normal to low blood pressure. [ 20 ] The promotor for gene SLC12A2, which encodes for NKCC1, contains binding sites for homeobox transcription factors SIX1 and SIX4 , which have been shown to ...
The sodium–potassium pump, a critical enzyme for regulating sodium and potassium levels in cells. Sodium ions (Na +) are necessary in small amounts for some types of plants, [1] but sodium as a nutrient is more generally needed in larger amounts [1] by animals, due to their use of it for generation of nerve impulses and for maintenance of electrolyte balance and fluid balance.
The membrane pump is primarily responsible for maintaining homeostasis of pH and sodium. [1] Defects in Na+/H+ antiporters may result in heart or kidney failure. [2] Angiotensin II upregulates this antiporter in the proximal convoluted tubule in order to promote Na + reabsorption and H + secretion. Na+/H+ exchangers are thought to be implicated ...
The proton pump relies on proton carriers to drive protons from the side of the membrane with a low H + concentration to the side of the membrane with a high H + concentration. In bacteriorhodopsin, the proton pump is activated by absorption of photons of 568nm wavelength , which leads to isomerization of the Schiff base (SB) in retinal forming ...