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Prazosin is an α 1-blocker that acts as a non-selective inverse agonist at α 1-adrenergic receptors, including of the α 1A-, α 1B-, and α 1D-adrenergic receptor subtypes. [24] It binds to these receptors with affinity (K i ) values of 0.13 to 1.0 nM for the α 1Α -adrenergic receptor, 0.06 to 0.62 nM for the α 1B -adrenergic receptor ...
The history of Canada covers the period from the arrival of the Paleo-Indians to North America thousands of years ago to the present day. The lands encompassing present-day Canada have been inhabited for millennia by Indigenous peoples , with distinct trade networks, spiritual beliefs, and styles of social organization.
Concluding a series of agreements between Canada, the United Kingdom, and the Hudson's Bay Company, Canada acquires Rupert's Land and the North-Western Territory, forming the Northwest Territories. In the aftermath of the Red River Rebellion, Manitoba is subdivided from the new territory in the area around Winnipeg , becoming Canada's fifth ...
The alpha blocker prazosin (Minipress) is most notorious for producing a first dose phenomenon. Other drugs of the same family, doxazosin (Cardura) and terazosin (Hytrin), can also cause this phenomenon, though less frequently.
This is a list of wars and armed conflicts in and involving Canada in chronological order, from the 11th century to the 21st century. It is divided into two main sections. The first section outlines conflicts that happened in what is now Canada before its confederation in 1867 .
Canada Flag Coat of arms Motto: A mari usque ad mare (Latin) "From Sea to Sea" Anthem: "O Canada" Royal anthem: "God Save the King" Capital Ottawa 45°24′N 75°40′W / 45.400°N 75.667°W / 45.400; -75.667 Largest city Toronto Official languages English French Demonym(s) Canadian Government Federal parliamentary constitutional monarchy • Monarch Charles III • Governor ...
E. W. Kemble's "Death's Laboratory" on the cover of Collier's (June 3, 1905). A patent medicine, also known as a proprietary medicine or a nostrum (from the Latin nostrum remedium, or "our remedy") is a commercial product advertised to consumers as an over-the-counter medicine, generally for a variety of ailments, without regard to its actual effectiveness or the potential for harmful side ...
The historiography of Canada deals with the manner in which historians have depicted, analyzed, and debated the history of Canada. It also covers the popular memory of critical historical events, ideas and leaders, as well as the depiction of those events in museums , monuments, reenactments, pageants and historic sites .