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Chloroquine (CQ) then becomes protonated (to CQ 2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form the FP-chloroquine complex; this ...
In dogs it is most commonly caused by mechanical irritation (such as by entropion, ectropion, or trichiasis), allergies, and keratoconjunctivitis sicca. Any bacterial infection is usually secondary. [72] Eye proptosis is a condition resulting in forward displacement and entrapment of the eye from behind by the eyelids. It is a common result of ...
Kennel cough is so named because the infection can spread quickly among dogs in the close quarters of a kennel or animal shelter. Viral and bacterial causes of canine cough are spread through airborne droplets produced by sneezing and coughing. These agents also spread through contact with contaminated surfaces.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Streptococcus canis is a group G beta-hemolytic species of Streptococcus. [1] It was first isolated in dogs, giving the bacterium its name. These bacteria are characteristically different from Streptococcus dysgalactiae, which is a human-specific group G species that has a different phenotypic chemical composition.
The two major bacterial pathogens are Anaplasma marginale and Anaplasma phagocytophilum. [3] These microorganisms are Gram-negative, [ 4 ] and infect red blood cells . [ 5 ] Once the host is infected with anaplasmosis, the immune system will try to fight off and kill the infected red blood cells, but will also kill healthy red blood cells. [ 2 ]
E. canis is a small, coccus bacterium with a single circular chromosome.Minute in size, E. canis is smaller than the other species in the genus Ehrlichia. [8] [10]The cell walls of this organism lack peptidoglycans and lipopolysaccharides typically present in at least small amounts in most other Gram-negative bacteria, which is believed to contribute to its ability to resist the immune ...
Brucella canis is a Gram-negative bacterium in the family Brucellaceae that causes brucellosis in dogs and other canids. It is a non-motile short-rod or coccus-shaped organism, and is oxidase, catalase, and urease positive. [1] B. canis causes infertility in both male and female dogs. It can also cause inflammation in the eyes.