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Myelosuppression, pulmonary infiltration and fibrosis. Secondary malignancies. [16] Lurbinectedin: IV Alkylates DNA. Metastatic small cell lung cancer. Hepatotoxicity [17] Mechlorethamine: IV, intra pleural, intra pericardial, topical Alkylates DNA. Hodgkin disease, chronic leukimia, lung cancer, polycythemia vera, T-cell lymphoma, mycosia ...
Methotrexate pneumonitis is a rare complication of therapy and appears to be reducing in frequency in most recent rheumatoid arthritis treatment trials. [39] In the context of rheumatoid arthritis interstitial lung disease, methotrexate treatment may be associated with a lower incidence of ILD over time. [citation needed]
Rheumatoid lung disease is a disease of the lung associated with RA, rheumatoid arthritis. Rheumatoid lung disease is characterized by pleural effusion, pulmonary fibrosis, lung nodules and pulmonary hypertension. Common symptoms associated with the disease include shortness of breath, cough, chest pain and fever.
[131] [58] This benefit from the combination of methotrexate with biologics occurs both when this combination is the initial treatment and when drugs are prescribed in a sequential or step-up manner. [58] Triple therapy consisting of methotrexate, sulfasalazine and hydroxychloroquine may also effectively control disease activity. [132]
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Treatment options for idiopathic pulmonary fibrosis are very limited, since no current treatment has stopped the progression of the disease. Because of this, there is no evidence that any medication can significantly help this condition, despite ongoing research trials. Lung transplantation is the only therapeutic option available in severe cases.
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