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The sodium–potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
During exercise, sodium channels normally open to allow influx of sodium into the muscle cells for depolarization to occur. But in hyperkalemic periodic paralysis, sodium channels are slow to close after exercise, causing excessive influx of sodium and displacement of potassium out of the cells. [15] [22]
For example, the sodium (Na +) and potassium (K +) ions are maintained by the sodium-potassium pump which uses energy (in the form of adenosine triphosphate (ATP)) to move three Na + out of the cell and two K + into the cell. Another example is the sodium-calcium exchanger which removes one Ca 2+ from the cell for three Na + into the cell. [12]
Potassium levels can fluctuate severely during the treatment of DKA, because insulin decreases potassium levels in the blood by redistributing it into cells via increased sodium-potassium pump activity. A large part of the shifted extracellular potassium would have been lost in urine because of osmotic diuresis.
Tubular secretion occurs at Proximal Convoluted Tubule (PCT) and Distal Convoluted Tubule (D.C.T); for example, at proximal convoluted tubule, potassium is secreted by means of sodium-potassium pump, hydrogen ion is secreted by means of active transport and co-transport, i.e. anti-porter, and ammonia diffuses into renal tubule.
Oral rehydration therapy (ORT) is a type of fluid replacement used to prevent and treat dehydration, especially due to diarrhea. [1] It involves drinking water with modest amounts of sugar and salts, specifically sodium and potassium. [1] Oral rehydration therapy can also be given by a nasogastric tube. [1]
A baclofen pump has been used to treat patients of all ages exhibiting muscle spasticity along with dystonia. The pump delivers baclofen via a catheter to the thecal space surrounding the spinal cord. The pump itself is placed in the abdomen. It can be refilled periodically by access through the skin. Baclofen can also be taken in tablet form [40]
Active transport is essential for various physiological processes, such as nutrient uptake, hormone secretion, and nig impulse transmission. For example, the sodium-potassium pump uses ATP to pump sodium ions out of the cell and potassium ions into the cell, maintaining a concentration gradient essential for cellular function. Active transport ...