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Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. It binds to the alpha-1 subunit of L-type calcium channels in a fashion somewhat similar to verapamil , another nondihydropyridine (non-DHP) calcium channel blocker. [ 28 ]
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
Block beta-1 receptors in the heart → stop the effects of catecholamines on the heart→ reduce heart rate, heart contractility and conduction velocity → reduce the workload of the heart [15] Side effects [16] Bradycardia; Hypotension; Heart Block; Impaired glucose metabolism; Central Nervous System effects: fatigue, depression, insomnia
Research shows asthma and depression are untreated or under-treated in children. Experts share signs of both in kids and share treatment options. These are the signs we often miss in children with ...
Starting a new medication for your mental health can be a time full of uncertainty. And there’s a lot of information about antidepressant medications out there.
While multiple studies have shown an improvement or efficacy rate of over 50%, the concern of severe side effects – such as suicidal ideation or suicidal attempts, worsening of symptoms, or increase in hostility – are still concerns when using antidepressants. [70]
The saying “knowledge is power” applies well in certain situations — like becoming a leader in your field of expertise or knowing the best places to eat (we all have different skills).
Medications to treat the toxic effects include: intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors and lipid emulsion. [1] [2] Extracorporeal membrane oxygenation may also be an option. [1] More than ten thousand cases of calcium channel blocker toxicity were reported in the United States in 2010. [2]