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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis .
Ondansetron was the first 5-HT 3 antagonist, developed by Glaxo around 1984. Its efficacy was first established in 1987, in animal models, [10] [11] and it was extensively studied over the following years. [12]
EDS can be a symptom of a number of factors and disorders. Specialists in sleep medicine are trained to diagnose them. Some are: Insufficient quality or quantity of night time sleep [5] Obstructive sleep apnea [6] Misalignments of the body's circadian pacemaker with the environment (e.g., jet lag, shift work, or other circadian rhythm sleep ...
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. [1]Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios.
are fast to absorb; [7] don't require water to consume; [7] have good taste (mouth feel); [7] don't provoke choking or suffocation; [7] have high microbial resistance ("due to the low moisture content in the final product, the Zydis formulation does not allow microbial growth"). [9]
It is crucial to aim for objective measures to quantify the sleepiness. A good measurement tool is the multiple sleep latency test (MSLT). It assesses the sleep onset latency during the course of one day—often from 8:00 to 16:00. [10] An average sleep onset latency of less than 5 minutes is an indication of pathological sleepiness. [11]